| 调节性T淋巴细胞与严重烧伤脓毒症 |
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| 引用本文： | Yao YM,Huang LF. 调节性T淋巴细胞与严重烧伤脓毒症[J]. 中华烧伤杂志, 2011, 27(2): 81-83. DOI: 10.3760/cma.j.issn.1009-2587.2011.02.001 |
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| 作者姓名： | Yao YM Huang LF |
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| 作者单位： | 解放军总医院第一附属医院全军烧伤研究所,北京,100048 |
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| 基金项目： | 国家自然科学基金,国家重点基础研究发展计划 |
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| 摘 要： |
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| 关 键 词： | 烧伤 脓毒症 免疫耐受 T淋巴细胞,调节性 |
The potential role of regulatory T cells in postburn sepsis |
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| Yao Yong-ming,Huang Li-feng. The potential role of regulatory T cells in postburn sepsis[J]. Chinese journal of burns, 2011, 27(2): 81-83. DOI: 10.3760/cma.j.issn.1009-2587.2011.02.001 |
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| Authors: | Yao Yong-ming Huang Li-feng |
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| Affiliation: | Burns Institute, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China. |
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| Abstract: | It has been demonstrated that severe burn per se may contribute to activation and proliferation of regulatory T cells (Treg). This characteristic phenomenon might allow Treg to function for a prolonged period of time to regulate immune response, and to induce suppression of T lymphocyte immune function. Different degrees of elevated levels of cytokines produced by Treg and activation markers on Treg surface could also be involved in the development of sepsis and fatal outcome in patients with severe burn. Thus, the regulation of Treg as a cellular therapeutic strategy might be important to the Th1/Th2 cytokine balance in burn patients complicated with sepsis. |
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| Keywords: | Burns Sepsis Immune tolerance T-lymphocytes,regulatory |
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