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| 甲磺酸酚妥拉明分散片的处方筛选及质量控制 | |
| 引用本文： | 吴小玉,常学军,李高. 甲磺酸酚妥拉明分散片的处方筛选及质量控制[J]. 中国医院药学杂志, 2003, 23(12): 736-738 |
| 作者姓名： | 吴小玉 常学军 李高 |
| 作者单位： | 1. 华中科技大学同济医学院,湖北,武汉,430030;湖北省医药工业研究院,湖北,武汉,430061 2. 武汉同济明治医药有限公司,湖北,武汉,430020 3. 华中科技大学同济医学院,湖北,武汉,430030 |
| 摘 要： | 目的：利用普通制剂技术制备起效快、服用方便的甲磺酸酚妥拉明分散片。方法：用正交实验设计方法对处方工艺进行筛选与优化制成甲磺酸酚妥拉明分散片，并建立质量标准，进行溶出度、稳定性考察。结果：甲磺酸酚妥拉明分散片处方合理、工艺简单、溶出快、稳定性好，符合中国药典2000年版质量标准。结论：本品可作为医院制剂开发。 |
| 关 键 词： | 甲磺酸酚妥拉明 分散片 正交实验 高效液相色谱法 |
| 文章编号： | 1001-5213(2003)12-0736-03 |
| 修稿时间： | 2003-02-15 |
Preparation and quality investigation of dispersible phentolamine mesylate tablets |
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| WU Xiao-Yu,CHANG Xue-Jun,LI Gao. Preparation and quality investigation of dispersible phentolamine mesylate tablets[J]. Chinese Journal of Hospital Pharmacy, 2003, 23(12): 736-738 | |
| Authors: | WU Xiao-Yu CHANG Xue-Jun LI Gao |
| Abstract: | OBJECTIVE To prepare a fast action and easy administration dispersible phentolamine mesylate tablets using co-mmon technology.METHODS The formulation and preparation technique were selected by orthogonal method.The quality stan-dard was established. The dissolution and stability were studied.RESULTS The selected formulation and preparation technique are good.The dispersible tablets have a fast dissolution and good stability.The quality conforms to the stand of CHP (2000).CONCLUSIONS The dispersible table could be used conveniently for clinic. |
| Keywords: | phentolamine mesylate dispersible tablet orthogonal method HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |