女性不孕患者解脲脲原体的检测及对7种抗生素的敏感性试验

目的：了解解脲脲原体在女性不孕患者中的致病作用和它的体外药物敏感情况。方法：运用支原体培养法检测女性不孕患者的Uu阳性率和微量肉汤稀释法对解脲脲原体进行7种抗生素的敏感性测定。结果：50例不孕组Uu阳性26例，50例对照组Uu阳性8例，两者有显著性差异。34例Uu阳性患者的支原体株对7种抗生素的高度敏感性依次为交沙霉素（82.35％）、司帕沙星（73.53％）、罗红霉素（67.65％）、强力霉素（35.29％）、美满霉素（23.53％）、氧氟沙星（17.65％）、环丙沙星（14.71％），发现5株对四环素类和喹诺酮类（除司帕沙星）交叉耐药。结论：对不孕症妇女及夫妻双方进行Uu常规检测和对Uu进行定期耐药性监测有助于不孕症的诊治。

Detection of Ureaplasna Urealyticum in Unpregnant Women and Determination of Its Susceptibility to 7 Antimi-crobial Drugs

OBJECTIVE To understand ureaplasma urealyticum' s pathogenicity in unpregnant women and its susceptibility to 7 antimicrobial drugs. METHODS By culture the presence rate of ureaplasma urealyticum (Uu) was detected in unpregnant women and broth microdilution method was used to susceptibility-test Uu to 7 drugp. RESULTS In the unpregnant group,26 cases were Uu positive in 50 patients, contrasted with the control group of 8 cases positive in 50 patients. The difference between two groups was statistically significant.The susceptible order of 34 Uu isolates to 7 drugs, from high to low, was josamycin (82.35 % ), sparfloxacin (73.53 % ), roxithromycin (67.65 % ), doxycycline (35.29% ), minocycline(23.53% ) ,ofloxacin( 17.65% ) and ciprofloxacin( 14.71% ) .5 inolates were cross-resistant to tetracycline and quinolonesf with the exception of sparfloxacin) . CONCLUSION Routine detection and periodic drug-sensitive test of Uu in unpregnant women as well as their husbands will help the diagnosis and treatment of unpregnancy.