| 大Y染色体与不良妊娠关系的探讨 |
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| 引用本文： | 孙玉萍,李强,孙道媛,刘忠强,孟凡会.大Y染色体与不良妊娠关系的探讨[J].齐鲁医学杂志,2003,18(3):303-304. |
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| 作者姓名： | 孙玉萍 李强 孙道媛 刘忠强 孟凡会 |
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| 作者单位： | 1. 青岛大学医学院附属医院生殖医学中心,山东,青岛,266003
2. 青岛市四方区妇幼保健所 |
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| 摘 要： | ①目的 探讨大Y染色体与不良妊娠之间的关系。②方法 常规制备外周血淋巴细胞染色体G显带标本，对606例检测者进行染色体核型分析。③结果 检出异常核型50例，其中22例为大Y染色体，大Y染色体检出率为3．63％，占异常核型的44．00％(22／50)。携带者配偶不明原因反复自然流产发生率为81．82％(18／22)，子代颅脑神经系统发育异常发生率为13．64％(3／22)，不明原因连续死胎发生率为4．55％(1／22)。④结论 大Y染色体核型具有一定的遗传效应。
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| 关 键 词： | Y染色体 染色体异常 染色体显带 妊娠 不良妊娠 |
| 文章编号： | 1008-0341(2003)03-0303-02 |
| 修稿时间： | 2003年3月7日 |
THE RELATIONSHIP BETWEEN BIG Y CHROMOSOME AND INFAUST PREGNANCY |
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| SUN Yu-ping,LI Qiang,SUN Dao-yuan,et al.THE RELATIONSHIP BETWEEN BIG Y CHROMOSOME AND INFAUST PREGNANCY[J].Medical Journal of Qilu,2003,18(3):303-304. |
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| Authors: | SUN Yu-ping LI Qiang SUN Dao-yuan |
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| Abstract: | Objective To study the relationship between big Y chromosome and infaust pregnancy. Methods Blood samples from 606 persons examined were cultured, processed, G-stained and analyzed routinely. Results An abnormal karyotype was detected in 50 cases, in which, 22 were big Y, the incidence was 3.63%, accounting for 44.00%(22/50) in abnormal karyotype. The incidence of repeated spontaneous abortion of unknown origin of the wives of big Y carriers was 81.82%(18/22), they gave birth children with brain abnormality was 13.64%(3/22), and successive fetal death 4.55%(1/22). Conclusion The big Y chromosome has a certain genetic effect. |
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| Keywords: | Y chromosome chromosome abnormalities chromosome staining |
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