| 4种抗癫痫药物单用与合用的疗效观察 |
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| 引用本文： | 王平全,李丹,沈金芳,苗玲.4种抗癫痫药物单用与合用的疗效观察[J].中国临床药学杂志,1996(4). |
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| 作者姓名： | 王平全 李丹 沈金芳 苗玲 |
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| 作者单位： | 上海第二医科大学仁济医院药剂科!上海200001(王平全，李丹，沈金芳)，上海第二医科大学仁济医院神经内科!上海200001(苗玲) |
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| 摘 要： | 报道128例癫痫患者4种抗癫痫药单用与合用的临床疗效以及中毒情况,对128例癫痫患者的血药浓度监测结果进行了分析,着重分析了PHT中毒病例与血药浓度的关系.举例说明TDM工作有助于诊断、处理药物过量中毒;对合并用药的合理性具有指导作用,建议尽量避免多药合用;同时必须密切注意PHT的饱和动力学特征.
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| 关 键 词： | 癫痫 药物监测 血药浓度 苯妥英钠 苯巴比妥 卡马西平 丙戊酸钠 |
ANALYSIS OF THE MONITORING OF SERUM ANTIEPILEPTIC DRUG LEVELS |
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| WANG Ping-quan,LI Dan,SHEN Jing-fang.ANALYSIS OF THE MONITORING OF SERUM ANTIEPILEPTIC DRUG LEVELS[J].Chinese Journal of Clinical Pharmacy,1996(4). |
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| Authors: | WANG Ping-quan LI Dan SHEN Jing-fang |
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| Abstract: | 128 cases of various types of epilepsy treated with phenytoin(PHT) ,carba-mazepine CBZ),phenobarbital (PB) or sodium valproate (VPA) were reported,serum concentration was measured,in which the toxic cases treated with PHT were chiefly analysed. The result showed as follows: Therapeutic Drug Monitoring (TDM) contributes to diagnosing and dealing with the toxication of excessive drugs. The kinetic characteristic of PHT (Michaelis-Menten kinetics) must be closely noticed. The reciprocal effect among different antiepileptic drugs are complex. Single drug treatment for clinical use was suggested. |
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| Keywords: | epilepsy therapeutic drug monitoring serum concentration sodium phenytoin phenobarbital carbamazepine sodium valproate |
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