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Improved pregnancy outcome following earlier splenectomy in women with immune thrombocytopenia: a 5-year observational study |
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| Authors: | Mohamed Rezk Alaa Masood Ragab Dawood Mahmoud Emara Hanan El-Sayed |
| Institution: | 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shibin El Kom, Menoufia Governorate, Egypt;2. Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Menoufia Governorate, Egypt;3. Department of Pediatrics, Faculty of Medicine, Menoufia University, Shibin El Kom, Menoufia Governorate, Egypt |
| Abstract: | Objective: To assess prospectively the maternal and fetal outcome in women with immune thrombocytopenic purpura (ITP) who undergone earlier splenectomy compared to women on medical therapy.Methods: A 5-year observational study included pregnant women in the first trimester previously diagnosed with primary ITP with 74 patients underwent splenectomy before pregnancy and 86 patients on medical therapy. Patients were followed throughout pregnancy and labour to record their obstetric outcome. Data were collected and tabulated.Results: There was a higher platelet count in the splenectomy group at enrollment (p?p?p?p?p?p?p?p?p?Conclusion: Earlier splenectomy in patients with ITP may have a beneficial impact on obstetric outcome and should be explained to patients wishing to get pregnant. Further larger multicenter studies are warranted to confirm or refute our findings. |
| Keywords: | Fetal outcome immune thrombocytopenia maternal outcome splenectomy |