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Utility of hepatobiliary scintigraphy in diagnosing or excluding biliary atresia in premature neonates and full-term infants with conjugated hyperbilirubinemia who received parenteral nutrition |
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| Authors: | Karine Barseghyan Rangasamy Ramanathan Thomas Chavez Susan Harlan Chuan-Hao Lin Tania Mitsinikos |
| Institution: | 1. Division of Neonatology, Children’s Hospital Los Angeles, Los Angeles, CA, USA;2. Division of Neonatology, LAC?+?USC Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA;3. kbarseghyan.usc@gmail.com;5. Division of Neonatology, LAC?+?USC Medical Center, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA;6. Division of Pediatric Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA;7. Division of Pediatric Gastroenterology and Hepatology, Children’s Hospital Los Angeles, Los Angeles, CA, USA |
| Abstract: | Purpose: Hepatobiliary scintigraphy (HBS) is used to aid in the diagnosis of Biliary Atresia in full-term infants with conjugated hyperbilirubinemia. There is little information on the utility of the HBS in premature infants with conjugated hyperbilirubinemia and infants with parenteral nutrition associated cholestasis (PNAC). The purpose of this study is to assess the utility of HBS in differentiating Biliary Atresia and PNAC in premature neonates and full-term infants who received parenteral nutrition (PN). Materials and methods: Retrospective data collection and analysis on infants who developed conjugated hyperbilirubinemia and had HBS performed during their stay at level IV neonatal intensive care unit between 2005 and 2015. Results: A total of 20 patients with exposure to PN had HBS; two patients were confirmed to have Biliary Atresia. There were no statistically significant differences between patients with Biliary Atresia versus PNAC in demographics, days on PN, or gamma glutamyl-transferase levels. Stool color was statistically significantly different between the two groups; patients with Biliary Atresia had acholic stools more consistently than patients without Biliary Atresia. HBS had 100% sensitivity, 17% specificity, positive-predictive value of 12%, and a negative-predictive value (NPV) of 100%. Conclusions: These data indicate that the ability of HBS to aid in diagnosing Biliary Atresia is poor in a population of preterm neonates and full-term infants with PNAC. Although there is 100% sensitivity, the poor specificity (17%) should be acknowledged when utilizing HBS to diagnose Biliary Atresia in this vulnerable patient population. NPV of 100% is helpful in ruling out Biliary Atresia in this population. |
| Keywords: | Conjugated hyperbilirubinemia Biliary Atresia hepatobiliary scintigraphy parenteral nutrition associated cholestasis neonate |