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Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats |
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| Authors: | M.I. Schubert M.V. Porkess N. Dashdorj K.C.F. Fone D.P. Auer |
| Affiliation: | 1. Division of Academic Radiology, School of Clinical Sciences, University of Nottingham, Queen''s Medical Centre, West Block, B Floor, Nottingham NG7 2UH, UK;2. School of Biomedical Sciences, University of Nottingham, Queen''s Medical Centre, West Block, E Floor, Nottingham NG7 2UH, UK |
| Abstract: | Rearing rats in social isolation from weaning induces robust behavioral and neurobiological alterations resembling some of the core symptoms of schizophrenia, such as reduction in prepulse inhibition of acoustic startle (PPI) and locomotor hyperactivity in a novel arena. The aim of this study was to investigate whether social isolation rearing induces volumetric remodeling of the limbic system, and to probe for anatomical structure–behavioral interrelations. |
| Keywords: | social isolation magnetic resonance imaging prefrontal cortex hippocampus prepulse inhibition schizophrenia |
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