Acute severe combined demyelination |
| |
Authors: | R Amit B Glick Y Itzchak Y Dgani S Meyeir |
| |
Institution: | (1) Division of Neurology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto, 15213 Pittsburgh, PA, USA;(2) Department of Pediatrics, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel;(3) Department of Radiology, Sheba Medical Center, Tel-Hashomer, Isarel;(4) Alyn Children's Orthopedic Hospital, Jerusalem, Israel |
| |
Abstract: | We present a second case in which Guillain-Barré syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) appeared simultaneously, both in acute and fulminant form. The patient, a 10-year-old girl, presented with acute onset of coma and flaccid, areflexic quadriparesis. The elevated CSF protein levels and delayed F waves fulfilled the criteria of GBS and an MRI study revealed extensive multifocal demyelination compatible with a diagnosis of ADEM. Prompt clinical response followed by complete recovery was achieved by treatment with corticosteroids. It is suggested that acute severe combined demyelination might constitute a separate entity in which the demyelinating process, involving simultaneously the central and the peripheral nervous systems, indicates immune response against a component of the myelin of one system carrying cross-antigenicity with the other. |
| |
Keywords: | Guillain-Barré syndrome Acute disseminated encephalomyelopathy Combined demyelination |
本文献已被 SpringerLink 等数据库收录! |
|