有机锗与环磷酰胺联合应用的研究

通过小鼠骨髓嗜多染红细胞微核实验，观察不同浓度有机锗（Ｇｅ－１３２）与环磷酰胺同时应用时的抗突变效应及其与剂量的关系。实验结果经２×Ｃ表非独立Ｘ２分割的多重比较统计处理，结果显示：在实验条件下，当Ｇｅ－１３２用量大于５０ｍｇ／ｋｇ时，与环磷酰胺有明显的协同作用，并有随Ｇｅ－１３２浓度增加而微核率升高的趋势。只有在适当的浓度（１２．５ｍｇ／ｋｇ），Ｇｅ－１３２才有抗突变作用。提示，Ｇｅ－１３２作为辅助用药在临床化疗或其他治疗时，应注意选择合适的用量范围。

Study on Combined Application of Organic Germanium and Cyclopbosphamide

The effect of organic germanium (Ge-132 ) in various concentrations on mutagenesis of cyclophosphamide was stud ied by micronucleus test in mouse bone marrow. The resultsshowed that. when the dosage of Ge-132 was above 50mg/kgbodyweight. Ge-132 had a synergetic effect with cyclophosphamide and a tendency that the micronucleus rate increased with growing concentration of Ge-132 was observed.Underthis experimental.ondition. only when its dosage was 12.5mg/kg bodyweight, Ge-132 had an antagonistic effect onmutagenesis of cyclophosphamide. This suggested that weshould adopt proper dosage when Ge-132 was usede as adjuvant in clinical chemotherapy or other therapys.