肥胖型和非肥胖型多囊卵巢综合征患者临床指标的对比研究

目的分析总结肥胖型和非肥胖型多囊卵巢综合征（PCOS）患者的内分泌和代谢特征。方法对肥胖型体质量指数（BMI）≥25 kg/m^2]PCOS患者（A组）18例、非肥胖型（BMI〈25 kg/m^2）PCOS患者（B组）34例进行临床体征测量、内分泌激素和代谢指标测定。结果 A组和B组比较,在体质量、BMI、腰围、臀围以及腰臀比方面,差别具有统计学意义（P〈0.01）;在促卵泡生成素（FSH）、黄体生成素（LH）、LH/FSH、泌乳素、雌二醇、睾酮和硫酸脱氢表雄酮各指标,差别均无统计学意义（P〉0.05）;在血脂方面,甘油三酯及载脂蛋白B两组间差别有统计学意义（P〈0.05）,总胆固醇、高密度脂蛋白和载脂蛋白A两组间差别无统计学意义（P〉0.05）;在空腹胰岛素和服糖后15,30,60,120 min胰岛素、稳态模型指数和胰岛素曲线下面积方面,两组间差别均有统计学意义（P〈0.01）。结论肥胖型PCOS患者较非肥胖型PCOS患者存在更严重的代谢紊乱,其远期并发症的防治应受到高度重视。

A Comparative Study of Clinical Indices between Obese and Non-obese Women with Polycystic Ovary Syndrome

Objective To study the endocrine and metabolic features of obese and non-obese women with polycystic ovary syndrome（PCOS）.Methods Fifty-two patients were divided into two groups according to their body mass index（BMI）： Group A,18 obese women（BMI≥25 kg/m^2） and Group B,34 non-obese women（BMI25 kg/m^2）.The clinical signs were measured and endocrine hormones and metabolic indices were determined.Results（1） Significant difference was found between Group A and Group B in weight,BMI,waist circumference,hip circumference and waist-to-hip ratio.（2） No significant difference was found between the two groups in follicle-stimulating hormone（FSH）,luteinizing hormone（LH）,LH/FSH,prolactin（PRL）,estradiol（E2）,testosterone（T） and dehydroepiandrosterone sulfate（DHEAS）.（3） No significant difference was found in total plasma cholesterol（TC）,high-density lipoprotein（HDL） and apolipoprotein-A（ApoA）,but the differences in triglyceride（TG） and apolipoprotein-B（ApoB） were significant（P〈0.05）.（4） Significant differences were found between the two groups in fasting insulin,insulin 15,30,60,120 min after oral glucose tolerance test（OGTT）,homeostasis model assessment of insulin resistance（HOMA-IR）,and the area under the curve（AUC） of insulin（P〈0.01）.Conclusion Obese women with polycystic ovary syndrome（PCOS）,in comparison with non-obese PCOS women,are likely to suffer more severe metabolic disorder.The long-term complication should receive due attention.