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一阶导数光谱法测定尼莫地平片的含量
引用本文:梁选革. 一阶导数光谱法测定尼莫地平片的含量[J]. 医药导报, 2002, 21(9): 580-581
作者姓名:梁选革
作者单位:广西壮族自治区北海市药品检验所,536000
摘    要:目的:建立测定尼莫地平片含量的方法,消除辅料干扰.方法:采用一阶导数光谱法,以243 nm(谷)与231 nm(峰)振幅值为定量依据.结果:相关系数r=0.999 8,平均回收率100.75%,RSD=0.70%.结论:该方法可靠,简便快速,结果准确.

关 键 词:尼莫地平  光谱法,一阶导数  含量测定
文章编号:1004-0781(2002)09-0580-02
修稿时间:2001-07-20

Determination of Nimodipine Content in Tablets by First Order Derivative Spectrophotometry
LIANG Xuan ge. Determination of Nimodipine Content in Tablets by First Order Derivative Spectrophotometry[J]. Herald of Medicine, 2002, 21(9): 580-581
Authors:LIANG Xuan ge
Abstract:Objective:To set up a method using first order derivative spectrophotometry for the determination of nimodipine content in tablets and to eliminate interference from excipients during the assay. Method:The content of nimodipine in tablets was determinated by means of first order derivative spectrophotometry,in which the quantitative calculations were based on the peak height at 231 nm and valley height at 243 nm. Results:The correlation coefficient was 0.999 8. The average recovery was 100.75%,with a relative standard deviation of 0.70%. Conclusion:The method is simple ,rapid,accurate and reliable.
Keywords:Nimodipine  First order derivative spectrophotometry  Content determination
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