| 国产酵母重组和CHO重组乙肝疫苗阻断母婴传播的免疫效果比较 |
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| 引用本文： | 黎国形,谭秀香.国产酵母重组和CHO重组乙肝疫苗阻断母婴传播的免疫效果比较[J].实用预防医学,1999,6(2):86-87. |
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| 作者姓名： | 黎国形 谭秀香 |
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| 作者单位： | 广西南宁市红十字会医院 |
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| 摘 要： | 目的评价国产重组乙肝疫苗酵母和重组ＣＨＯ乙肝疫苗阻断母婴传播效果。方法应用两种乙肝疫苗，对母亲ＨＢｓＡｇ和ＨＢｅＡｇ双阳性的新生儿进行免疫，并以国产血源乙肝疫苗作对照。结果国产酵母重组和ＣＨＯ重组乙肝疫苗具有较好的安全性，免疫第９、１２个月，阻断母婴传播的近期保护效果分别为１０００％和９６４％。结论上述两种国产基因重组乙肝疫苗与３０ｕｇ血源乙肝疫苗＋ＨＢＩＧ效果（９５０％）相同。
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| 关 键 词： | 重组酵母乙肝疫苗 重组CHO乙肝疫苗 母婴传播阻断 |
Comparison of Effect of Recombinant Yeast-derived and Chinese Hamster Ovary-derived
Hepatitis B Vaccines in Interruption of Perinatal Transmission of Hepatitis B Virus |
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Guoxing,TAN Xiuxiang,TENG Qingjiao,et al..Comparison of Effect of Recombinant Yeast-derived and Chinese Hamster Ovary-derived
Hepatitis B Vaccines in Interruption of Perinatal Transmission of Hepatitis B Virus[J].Practical Preventive Medicine,1999,6(2):86-87. |
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| Authors: | LI
Guoxing TAN Xiuxiang TENG Qingjiao |
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| Institution: | LI
Guoxing,TAN Xiuxiang,TENG Qingjiao,et al. The Red Cross Society Hospital of
Nanning,Guangxi,530012 [ |
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| Abstract: | Objective To evaluate the effect of recombinant
yeast-derived(YDV) and Chinese hamster ovary-derived(CHO) hepatitis B vaccines in
interruption of perinatal transmission of hepatitis B virus. Methods The two kinds of
recombinant hepatitis B vaccines were implemented for newborns whose mothers were both
HBsAg and HBeAg positive, and compared to plasma-derived vaccine. Results Both
recombinant YDV and CHO hepatitis B vaccines were safe. The protective efficacy of
interruption of perinatal transmission were 100% and 96.4% after 9 and 12 months of
vaccination respectively. Conclusion The effect of both recombinant hepatitis B vaccines is the
same as that of 30 ug plasma-derived vaccine plus HBIG(95.0%). |
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| Keywords: | Recombinant yeast-derived hepatitis B vaccine Recombinant Chinese hamster ovary-derived hepatitis B vaccine Interruption of perinatal transmission |
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