单眼弱视儿童视网膜神经纤维层和黄斑中心凹厚度分析

目的 比较单眼弱视儿童弱视眼与非弱视眼的视盘周围神经纤维层（RNFL）和黄斑中心凹厚度的差异。方法 选取单眼弱视儿童23人，利用光学相干断层扫描（OCT）技术分别检测双眼视盘上方、颞侧、下方、鼻侧4个象限RNFL厚度及RNFL平均厚度，检测黄斑中心凹1 mm直径区域平均厚度和黄斑中心凹最小厚度，比较同一受检者弱视眼与非弱视眼的差异。结果 弱视眼视盘颞侧象限RNFL厚度小于非弱视眼(t=-4.671，P=0.000 1)，而视盘上方、下方、鼻侧象限RNFL厚度及RNFL平均厚度与非弱视眼比较，差异无统计学意义(P>0.05)。弱视眼与非弱视眼黄斑中心凹1 mm直径区域的平均厚度比较，差异无统计学意义(t=0.082 3，P=0.935 1)；而弱视眼黄斑中心凹最小厚度小于非弱视眼(t=-2.371 0，P=0.026 9)。结论 单眼弱视儿童的弱视眼与非弱视眼在视盘周围RNFL与黄斑的组织结构上存在一定差异。

Thickness of retinal nerve fiber layer and central fovea of macula in children with unilateral amblyopia

Objective To compare the thickness of peripapillary retinal nerve fiber layer(RNFL) and central fovea of macula between amblyopic eyes and non-amblyopic eyes in children with unilateral amblyopia.Methods Twenty-three children with unilateral amblyopia were selected,the thickness of RNFL around optic disk(superior,temporal,inferior and nasal quadrants) and mean thickness of RNFL were measured by optical coherence tomography(OCT),the mean thickness of central fovea of 1 mm in diameter and the smallest thickness of cental fovea of macula were examined,and the differences between amblyopic eyes and non-amblyopic eyes were compared.Results The thickness of RNFL in the temporal quadrant in amblyopic eyes was smaller than that in non-amblyopic eyes(t=-4.671,P=0.000 1),while there was no significant difference in the thickness of RNFL in the superior,inferior or nasal quadrants and the mean thickness of RNFL between amblyopic eyes and non-amblyopic eyes(P>0.05).There was no significant difference in the mean thickness of fovea of 1 mm in diameter between amblyopic eyes and non-amblyopic eyes(t=0.082 3,P=0.935 1),while the smallest thickness in central fovea of macula in amblyopic eyes was smaller than that in non-amblyopic eyes(t=-2.371 0,P=0.026 9).Conclusion There exist differences in peripapillary RNFL and structure of macula between amblyopic eyes and non-amblyopic eyes in children with unilateral amblyopia.