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| 金黄地鼠和大鼠高血脂模型的应用研究 | |
| 引用本文： | 李林鹏,孙浚雯,曹永兵,任天舒,姜远英,孙德好.金黄地鼠和大鼠高血脂模型的应用研究[J].药学实践杂志,2007,25(6):369-371. |
| 作者姓名： | 李林鹏 孙浚雯 曹永兵 任天舒 姜远英 孙德好 |
| 作者单位： | 1. 第二军医大学药学院药理学教研室,上海,200433 2. 第二军医大学流行病学教研室,上海,200433 3. 中国人民解放军第411医院,上海,200081 |
| 摘 要： | 目的:通过比较辛伐他汀在Wistar大鼠与金黄地鼠两种高血脂模型中的作用,分析两种高血脂模型的合理应用。方法:取Wistar大鼠和金黄地鼠各30只,大鼠体重200~230 g,金黄地鼠体重100~130 g,各随机分成空白对照组、模型对照组以及辛伐他汀组各10只。确认模型建立成功后,两给药组分别给予辛伐他汀10 mg/(kg.d),并于给药第14、28天测定血清TC和LDL-C。分析辛伐他汀在两种动物高血脂模型中的作用。结果:辛伐他汀能抑制Wistar大鼠血脂升高的趋势和降低高血脂症金黄地鼠的血脂水平。Wistar大鼠对辛伐他汀的降脂作用较金黄地鼠更为敏感。结论:Wistar大鼠高血脂模型对辛伐他汀的降脂作用更为敏感,作为某些降血脂药物如他汀类活性筛选动物模型具有其优势。而金黄地鼠胆固醇的合成代谢与人类更为接近,其高血脂模型更有利于进行某些降血脂新药的临床前评价。 |
| 关 键 词： | 高血脂症 金黄地鼠 Wistar大鼠 辛伐他汀 |
| 文章编号： | 1006-0111（2007）06-0369-03 |
| 收稿时间： | 2007-04-11 |
| 修稿时间： | 2007年4月11日 |
Studies on the application of the hyperlipemia model of golden hamster and Wistar rat |
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| LI Lin-peng,SUN Jun-wen,CAO Yong-bing,REN Tian-shu,JIANG Yuan-ying and SUN De-hao.Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J].The Journal of Pharmaceutical Practice,2007,25(6):369-371. | |
| Authors: | LI Lin-peng SUN Jun-wen CAO Yong-bing REN Tian-shu JIANG Yuan-ying and SUN De-hao |
| Institution: | Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China;Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China;Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China;Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China;Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China;Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China |
| Abstract: | |
| Keywords: | hyperlipemia hamster Wistar rat simvastatin |
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