右美托咪定对小儿神经外科麻醉后苏醒期躁动的影响

目的评价右旋美托咪定对小儿神经外科手术患者七氟烷麻醉后苏醒期躁动的影响。方法择期实施神经外科手术的患儿60例,随机分为实验组(D组)和对照组(C组),每组30例,两组均为七氟烷吸入诱导。D组静脉内右旋美托咪定1μg/kg负荷并以0.4μg(/kg h)持续泵入,复合七氟烷维持麻醉;C组给予等容积的生理盐水,复合七氟烷维持麻醉。观察并比较两组患儿苏醒期的躁动情况以及血流动力学的变化。结果两组患儿麻醉时间、手术时间、术后拔管时间和停留PACU时问和术前躁动评分无统计学差异(P>0.05);D组的术后躁动评分和躁动发生率低于C组(P<0.05)。结论小儿神经外科手术中,应用右旋美托咪定可以减少七氟烷麻醉后苏醒期躁动。

Effect of Dexmedetomidine on Emergence Agiation in Children After Sevoflurane Anesthesia Undergoing Neurosurgery Procedure

Ojective To evaluate the effect of dexmedetomidine on the emergence agiation in children after sevoflurane anesthesia undergoing neurosurgery procedure. Methods Sixty childrens undergoing elective neurosurgery procedure were randomly divided into two groups （group C and D） with thirty cases each. After mask induction with sevoflurane, group D received iv dexmedetomidine 1 μg/kg, follow by 0.4μg/（kg.h）,and group C received iv NS. Anesthesia was maintained with sevofturane and oxygen. Observated and comparised restlessness and hemodynamic changes of children in each groups. Results There was no significant difference in time of anesthesia, time of operation, time of extubation and time stayed in PACU and scores for emergence agitation before anesthesia（P〉0.05）. There were significantly difference in scores of emergence agitation after entrance into PACU in group D, compared with group C（P〈0.05）. The rate of emergence agitation were significantly lower in group D than that of group C（P〈0.05）. Conclusion An intraoperative infusion of dexmedetomidine combined with sevoflurane provided satisfactory intraoperative conditions for pediatric neurosurgery procedure. The incidence and duration of emergence agiation was lowered with dexmedetomidine.