| 髓源性抑制细胞和调节性T细胞在感染和肿瘤微环境中的免疫抑制机制 |
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| 引用本文： | 赵金全,王剑松,詹辉.髓源性抑制细胞和调节性T细胞在感染和肿瘤微环境中的免疫抑制机制[J].国际肿瘤学杂志,2013,40(6):428-431. |
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| 作者姓名： | 赵金全 王剑松 詹辉 |
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| 作者单位： | 650101,昆明医科大学第二附属医院泌尿外科 |
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| 摘 要： | 髓源性抑制细胞(MDSC)和调节性T细胞(Treg)是重要的抑制性免疫细胞,在炎症、感染和肿瘤中大量扩增,可通过多种机制抑制机体抗肿瘤免疫,促进肿瘤生长和转移.寻找肿瘤微环境中MDSC、Treg细胞升高的原因及清除方法,已成为肿瘤免疫治疗的研究热点.
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| 关 键 词： | 免疫抑制法 炎症 肿瘤 T淋巴细胞 调节性 髓源性抑制细胞 |
Immunosuppression mechanism of MDSCs and regulatory T cells in inflammation and tumor microenvironment |
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| ZHAO Jin-quan
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WANG Jian-song
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ZHAN Hui.Immunosuppression mechanism of MDSCs and regulatory T cells in inflammation and tumor microenvironment[J].Journal of International Oncology,2013,40(6):428-431. |
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| Authors: | ZHAO Jin-quan WANG Jian-song ZHAN Hui |
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| Institution: | Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China |
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| Abstract: | Myeloid-derived suppressor cells (MDSCs) and regulatory T cell (Treg) in the tumor microenvironment are important inhibitory immune cells. Research finds that MDSC and Treg increase in large number under the conditions of inflammation, infection and cancer and are able to suppress the immunity system and promote tumor-cell invasion and metastasis through multiple mechanisms. Finding the causes of resulting in the increase of MDSCs and Treg in tumor microenvironment and the eliminating methods have become new focuses in the field of anti-tumor immunotherapy. |
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| Keywords: | Immunosuppression Inflammation Neoplasms T-lymphocytes regulator Myeloidderived suppressor cells |
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