| 三氧化二砷在胃癌治疗中的应用 |
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| 引用本文： | 于瑶,杨宇. 三氧化二砷在胃癌治疗中的应用[J]. 国际肿瘤学杂志, 2013, 40(6): 460-462 |
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| 作者姓名： | 于瑶 杨宇 |
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| 作者单位： | 150086,哈尔滨医科大学附属第二医院肿瘤内科 |
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| 摘 要： | 三氧化二砷(As2O3)是中药砒霜的主要成分,最初被用于治疗血液系统疾病.近年研究发现,其对多种实体瘤也有良好疗效,其中对胃癌疗效显著.研究证实,As2O3可以抑制胃癌细胞增殖及转移,诱导胃癌细胞凋亡和保护性自噬,抑制胃癌淋巴管和新生血管形成,影响胃癌细胞内端粒相关蛋白的表达.
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| 关 键 词： | 胃肿瘤 细胞凋亡 自噬 三氧化二砷 |
Application of arsenic trioxide in gastric cancer treatment |
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| YU Yao , YANG Yu. Application of arsenic trioxide in gastric cancer treatment[J]. Journal of International Oncology, 2013, 40(6): 460-462 |
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| Authors: | YU Yao YANG Yu |
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| Abstract: | Arsenic trioxide（As2O3）is the main component of traditional Chinese medicine arsenic, which was initially used in the treatment of blood system diseases. In recent years, studies have found that it also has a good effect on a variety of solid tumors, especially gastric cancer. It has been confirmed that As2O3 can inhibit proliferation and metastasis of gastric cancer cells, induce apoptosis and protective autophagy, inhibite lymphatic formation and angiogenesis, affect the expression of telomere-related proteins in gastric cancer cells. |
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| Keywords: | Stomach neoplasms Apoptosis Autophagy Arsenic trioxide |
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