三氧化二砷在胃癌治疗中的应用

三氧化二砷(As2O3)是中药砒霜的主要成分,最初被用于治疗血液系统疾病.近年研究发现,其对多种实体瘤也有良好疗效,其中对胃癌疗效显著.研究证实,As2O3可以抑制胃癌细胞增殖及转移,诱导胃癌细胞凋亡和保护性自噬,抑制胃癌淋巴管和新生血管形成,影响胃癌细胞内端粒相关蛋白的表达.

Application of arsenic trioxide in gastric cancer treatment

Arsenic trioxide（As₂O₃）is the main component of traditional Chinese medicine arsenic, which was initially used in the treatment of blood system diseases. In recent years, studies have found that it also has a good effect on a variety of solid tumors, especially gastric cancer. It has been confirmed that As₂O₃ can inhibit proliferation and metastasis of gastric cancer cells, induce apoptosis and protective autophagy, inhibite lymphatic formation and angiogenesis, affect the expression of telomere-related proteins in gastric cancer cells.