急性孤立性桥脑梗死患者早期神经功能恶化的相关因素分析

目的: 探究急性孤立性桥脑梗死(acute isolated pontine infarction, AIPI)患者早期神经功能恶化(early neurological deterioration, END)的相关因素。方法: 回顾性分析2016年1月至2019年1月于江苏大学附属医院神经内科收治的AIPI患者114例，根据患者END发生与否分为END组（60例）和非END组（54例），收集患者相关人口学和临床资料，应用多因素Logistic回归分析AIPI患者发生END的独立危险因素。结果： 两组患者在入院时美国国立卫生研究院卒中量表（NIHSS）评分、空腹血糖、基底动脉穿支疾病以及小动脉疾病存在统计学差异(P均＜0.05)；基底动脉穿支疾病为END发生的独立危险因素[OR=5.614, 95%CI： 1.165~27.055]。结论： AIPI患者END可能与基底动脉穿支疾病相关。

Relative factors on the early neurological deterioration in the patients with acute isolated pontine infarction

Objective: To explore the related factors of early neurological deterioration (END) in patients with acute isolated pontine infarction(AIPI). Methods: A retrospective analysis of the patients with AIPI was conducted, these patients were treated in the Department of Neurology, Affiliated Hospital of Jiangsu University from January 2016 to January 2019. According to the occurrence of END, the patients were divided into END group and non-END group. The data of patients were collected and the independent risk factors of END in AIPI patients were analyzed by multivariate Logistic regression. Results: There were significant differences in NIHSS score, fasting blood sugar, basilar artery perforator disease and small artery disease between the two groups at admission (all P＜0.05). Basilar artery perforator disease was an independent risk factor for END (OR=5.614，95%CI 1.165~27.055).Conclusion: Basilar artery perforator disease may be attributed to END in patients with AIPI.［Key words］pontine; cerebral infarction; deterioration of disease; risk factors