| 热休克蛋白27在脊髓缺血再灌注的防护作用 |
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| 引用本文： | 徐建平,郭文荣,林国兵.热休克蛋白27在脊髓缺血再灌注的防护作用[J].中国骨伤,2012,25(10):880-882. |
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| 作者姓名： | 徐建平 郭文荣 林国兵 |
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| 作者单位： | 南京军区福州总医院第一附属医院骨科,福建莆田,351100 |
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| 摘 要： | 热休克蛋白27(heat shock protein,HSP27)属于热休克蛋白家族中的小分子量家族,本文在回顾收集大量相关文献的基础上,分析了HSP27在脊髓缺血再灌注损伤中的表达意义和机制,阐明了HSP27具有抑制NO的生成、维持细胞蛋白稳定和加速细胞损伤修护的功能,同时HSP27还具有抗细胞凋亡、保护线粒体、抑制核转录因子活化等相关作用。进一步表明了热休克蛋白27在脊髓缺血再灌注中的保护作用。
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| 关 键 词： | 热休克蛋白27 脊髓 缺血 再灌注损伤 综述文献 |
| 收稿时间： | 2011/8/16 0:00:00 |
Safty action of heat shock protein 27 in reperfusion after spinal marrow ischemia |
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| XU Jian-ping,GUO Wen-rong and LIN Guo-bing.Safty action of heat shock protein 27 in reperfusion after spinal marrow ischemia[J].China Journal of Orthopaedics and Traumatology,2012,25(10):880-882. |
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| Authors: | XU Jian-ping GUO Wen-rong and LIN Guo-bing |
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| Institution: | Department of Orthopaedics,the First Affiliated Hospital of Fuzhou General Hospital of Nanjing Military,Putian 351100,Fujian,China;Department of Orthopaedics,the First Affiliated Hospital of Fuzhou General Hospital of Nanjing Military,Putian 351100,Fujian,China;Department of Orthopaedics,the First Affiliated Hospital of Fuzhou General Hospital of Nanjing Military,Putian 351100,Fujian,China |
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| Abstract: | Heat shock protein 27 belongs to the heat shock protein family in the small molecular weight family. This review collected a number of literature to analyze the expression meaning and mechanism of HSP27,expounded HSP27 with inhibition of NO production,maintenance of cell protein stability and accelerated cell damage repair function. At the same time,HSP27 also has a resistance to apoptosis,protecting mitochondria,inhibiting activation of nuclear factor and other related functions. The heat shock protein 27 has protection in spinal cord ischemia-reperfusion. |
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| Keywords: | Heat shock protein 27 Spinal cord Ischemia Reperfusion injury Review literature |
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