| 复方光明胶囊对实验性大鼠视网膜光损伤的作用 |
| |
| 引用本文： | 彭华,马珊,王维绮,卜文超,董玉,马素红. 复方光明胶囊对实验性大鼠视网膜光损伤的作用[J]. 昆明医学院学报, 2011, 32(11): 31-35 |
| |
| 作者姓名： | 彭华 马珊 王维绮 卜文超 董玉 马素红 |
| |
| 作者单位： | 1. 云南省中医医院,云南昆明,654100
2. 昆明医学院附属口腔医院,云南昆明,650031 |
| |
| 基金项目： | 云南省科技厅科学研究基金资助项目(2009ZC153M); 云南省教育厅科学研究基金资助项目(09Y0237) |
| |
| 摘 要： | 目的研究视网膜光损伤动物模型,观察复方光明胶囊对手术显微镜光损伤大鼠视网膜作用的超微结构.方法SD大鼠30只（60只眼）,随机分为高、中、低剂量组,模型组和正常组,每组6只动物（12只眼）.造模前7 d给药,连续灌胃2周.除正常组以外各组实验用大鼠距角膜（150±3）mm照射,使大鼠眼在接受手术显微镜水平位时照度为（22 000±1 000）Lux,60 min的持续光照射.光照后继续给药1周,观察各组视网膜电镜的变化差异.结果正常大鼠视网膜组织结构层次清楚,内、外节视杆排列整齐、规则.内、外核层排列紧密,染色均匀;光照后各组均可见外核层变薄而稀疏;光感受器视杆外节排列紊乱,膜盘间隙部分断裂;内节线粒体肿胀;外核层细胞核染色质固缩,分布不均匀.药物剂量高、中、低组较模型组有改善.结论手术显微镜视网膜光损伤动物模型造模成功,复方光明胶囊各剂量组对视网膜光损伤后有一定的保护作用.
|
| 关 键 词： | 复方光明胶囊 视网膜光损伤 透射电镜 |
Effect of Compound Light Capsule on Rats' Retinal Light Injury Induced by Operation Microscope,an Electron Microscope Observation |
| |
| PENG Hua,MA Shah,WANG Wei-qi,PU Wen-chao,DONG Yu,MA Su-hong. Effect of Compound Light Capsule on Rats' Retinal Light Injury Induced by Operation Microscope,an Electron Microscope Observation[J]. Journal of Kunming Medical College, 2011, 32(11): 31-35 |
| |
| Authors: | PENG Hua MA Shah WANG Wei-qi PU Wen-chao DONG Yu MA Su-hong |
| |
| Affiliation: | PENG Hua1),MA Shan1),WANG Wei-qi 2),PU Wen-chao1),DONG Yu1),MA Su-hong1)(1)Yunnan Hospitao of Taditional Chinese Medicine,Kunming Yunnan 654100,2)The Affiliated Stomatology Hospital of Kunming Medical University,Kunming Yunnan 650031,China) |
| |
| Abstract: | Objective To establish the rat model of retinal light injury,and observe the effect of Compound Light Capsule on the rat retinal light injury under electron microscope.Methods 30 SD rats(60 eyes)were divided into high dose group,middle dose group,low dose group,sham group,and normal group in random,6 SD rats(12 eyes)in each group.Rats were intragastrically administered with Compound Light Capsule 7 days before modeling,and the administration lasted for 2 weeks.Experimental rats in each group were exposured ... |
| |
| Keywords: | Compound light capsule Retinal light injury Electron microscope |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
