Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma with a CD15(+)CD30(-) phenotype |
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Authors: | Yoshizawa Naho Yagi Hiroaki Horibe Takahiro Takigawa Masahiro Sugiura Makoto |
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Affiliation: | Department of Dermatology, Shizuoka Municipal Shimizu Hospital, 1231 Miyakami Shimizu, Shizuoka 424-8636, Japan. naho@suite.plala.or.jp |
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Abstract: | Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma (CD8(+)TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin's lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8(+)TCL, in which lymphoma cells are CD15(+)CD30(-) with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8(+)TCL might be associated with the presence of this molecule in our case. |
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