| EFFECTS OF GLUTAMATE ON SODIUM CHANNEL IN ACUTELY DISSOCIATED HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF RATS |
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| 作者姓名： | 高宾丽 伍国锋 杨艳 刘智飞 曾晓荣 |
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| 作者单位： | [1]Department of Emergency Neurology [2]the First Affiliated Hospital [3]Guiyang Medical College [4]Department of Myocardial Electrophysiology [5]Luzhou Medical College |
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| 摘 要： | Objective To observe the effects of glutamate on sodium channel in acutely dissociated hippocampal CA1 pyramidal neurons of rats.Methods Voltage-dependent sodium currents (INa) in acutely dissociated hippocampal CA1 pyramidal neurons of neonate rats were recorded by whole-cell patchclamp of the brain slice technique when a series of doses of glutamate (100-1000μmol/L) were applied.Results Different concentrations of glutamate could inhibit INa,and higher concentration of glutamate affected greater inhibitio...
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