Clinical applications of telomerase in cancer treatment |
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| Affiliation: | 1. Section of Pharmacology, Medical Oncology, Department of Neuroscience, University of Rome ‘Tor Vergata’ Rome, Italy;2. Istituto Dermopatico dell’immacolata’ (IDIIRCCS), Rome, Italy;1. Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran;2. National Program Manager for Malaria Control, Ministry of Health and Medical Education, Tehran, Iran;1. Reinhard Selten Laboratory, Nankai University, China;2. China Academy of Corporate Governance, Nankai University, China;3. Business School of Nankai University, China;1. Research Unit of Histology & Embryology, Dept. Experimental & Clinical Medicine, University of Florence, Viale G.Pieraccini 6, 50139 Florence, Italy;2. Section of Anatomy & Histology, Dept. Experimental & Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy;1. Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, China;2. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China;3. Institute of Biomedical Sciences, College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Shandong Normal University, Jinan, China;1. Microbial Interface Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany;2. Molecular and Experimental Mycobacteriology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany;3. Institute of Immunology, Christian-Albrechts-University of Kiel, 24109 Kiel, Germany;4. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel, Parkallee 1-40, 23845, Borstel, Germany;1. Department of Environmental Science, University of Calcutta, Kolkata, India;2. Department of Civil and Environmental Engineering, Birla Institute of Technology, Mesra, India |
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| Abstract: | Telomerase activity has been found in most cancer cells, but not in the majority of normal differentiated tissues. Therefore, telomerase has been considered a relatively selective and widely expressed tumor marker to be used as a diagnostic tool, and in some cases, as a potential prognostic indicator. Telomerase activity can also be used to evaluate chemosensitivity of neoplastic cells obtained from cancer patients, by measuring residual telomerase activity after drug treatment. Finally, telomerase has been considered to represent a suitable target for designing new anticancer strategies. This review focuses on present and future clinical applications of telomerase studies in cancer management. |
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