补肾活血法对骨关节炎相关因子调控作用研究进展

补肾活血法是中国传统医学治疗骨关节炎的经典传统治法之一,临床疗效确切。为了探讨补肾活血法治疗骨关节炎的机制,对近年来补肾活血法治疗骨关节炎的基础文献进行整理、分析、总结,发现白细胞介素（interleukin,IL）、肿瘤坏死因子（tumornecrosisfactor,TNF）、一氧化氮（nitricoxide,NO）等细胞因子在骨关节炎中扮演重要的角色,补肾活血法可以有效降低这些因子水平,从而改善慢性滑膜炎症,控制和减轻软骨破坏,减轻疼痛,增强肌肉耐力及关节活动能力等。其对骨关节炎的治疗可能是基于对多因子水平调控及滑膜、软骨等多靶点、环节的干预实现的,但是补肾活血法治疗骨关节炎的主要效应途径及靶点还需要进一步深入的研究。

Research progress on applying the method of tonifying kidney and activating blood on regulating cy-tokines associated with osteoarthritis

The method of tonifying kidney and activating blood is one of the classical therapeutical methods of traditional Chinese medicine in the treatment of osteoarthritis and having good effect. In order to investigate the mechanism in tonifying kidney and activating blood on treating osteoarthritis, literatures on applying tonifying kidney and activating blood on treating osteoarthritis in recent years are collected, ana-lysed and summarised and it is found that interleukin, tumor necrosis factor, nitric oxide and other cyto-kines play an important role in osteoarthritis. Tonifying kidney and activating blood method can effectively reduce the level of these factors, and improve the chronic synovial inflammation, control and reduce the de-struction of articular cartilage, relieve the pain, improve muscle endurance and joint activities etc. The treatment of osteoarthritis is based on regulation of multiple factor and intervention of synovial, cartilage and other targets. But the main effective way and target point in Bushen Huoxue treatment of osteoarthritis still need further study.