| 乙型肝炎患者血清中HBV的前S_1和前S_2蛋白的检测及其意义 |
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| 引用本文： | 姜节洪. 乙型肝炎患者血清中HBV的前S_1和前S_2蛋白的检测及其意义[J]. 现代免疫学, 1991, 11(2): 90-93 |
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| 作者姓名： | 姜节洪 |
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| 作者单位： | 上海第二医科大学附属瑞金医院传染病科(陆志檬，姜節洪，金根娣，王耆煌)，法国巴斯德研究院微生物免疫室(A.Budkowska J.Pillot) |
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| 摘 要： | 乙肝病毒的外壳是由S、前S_1、前S_2蛋白所组成。我们用抗前S_1和抗前S_2单克隆抗体检测106例病毒性肝炎的前S_1蛋白和前S_2蛋白,结果表明急性乙肝早期的前S_1、前S_2蛋白(n=16,75％和87,5％)明显高于急性乙肝恢复期(n=33,21.2％、12.1％);慢活肝的前S_2蛋白(n=15,93.7％)明显高于慢迁肝(n=18,55.6％),前S_2蛋白与HBsAg、eAg和HBV-DNA呈正相关(P<0.05,<0.05<0.001),支持前S_2蛋白的出现和HBV复制有关。
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| 关 键 词： | 乙肝病毒 前S1蛋白 前S2蛋白 检测 |
DETECTION AND SIGNIFICANCE OF PRE-S1/PRE S2 PROTEINS IN THE SERUM OF PATIENTS WITH HBV INFECTION |
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| Abstract: | The envelope of HBV consists of proteins S, Pre-S1 and Pre-S2. The Pre-S1 and Pre-S2 protein in the serum of 106 patients have been detected with anti-PreS1 and anti-PreS2 monoclonal antibodies. The results showed that positive rates of Pre-Sl and Pre-S2 proteins in acute HB patients during early stage (n = 16,75% and 87.5%) were significantly higher than those during convalescene (n = 33, 21.1%, 12.1%). The positive rate of Pre-S2 protein in CAH patients (n = 15, 83.7%) was significantly higher than that in CPH patients (n = 18, 55.6%). In addition, Pre-S2 protein was positively correlated to HBsAg, HBeAg and HBV-DNA, suggesting the appearance of Pre-S2 proten being related to the replication of HBV. |
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