| CBN对脑反复缺血再灌注小鼠的保护作用研究 |
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| 引用本文： | 金文,孙虹,孙立红,杜力军.CBN对脑反复缺血再灌注小鼠的保护作用研究[J].中药药理与临床,2004,20(2):15-16. |
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| 作者姓名： | 金文 孙虹 孙立红 杜力军 |
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| 作者单位： | 1. 中国医学科学院·中国协和医科大学药用植物研究所,北京,100094
2. 清华大学生物科学与技术系,北京,100084 |
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| 摘 要： | 目的:观察CBN对脑缺血再灌注小鼠的保护作用.方法:采用小鼠脑反复缺血再灌注模型,从形态学、SOD活性、MDA含量、ATPase含量等方面观察了CBN对脑保护作用.结果:CBN可显著增加缺血再灌注脑海马区存活锥体细胞数,保护SOD活性,减少MDA的生成,减轻ATP酶活性的降低.结论:CBN对脑反复缺血再灌注小鼠具有脑保护作用.
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| 关 键 词： | 缺血再灌注 锥体细胞 |
Protection of CBN from the mouse brain damaged by ischemia-reperfusion |
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| Jin Wen,Sun Hong,Sun Lihong,Du Lijun.Protection of CBN from the mouse brain damaged by ischemia-reperfusion[J].Pharmacology and Clinics of Chinese Materia Medica,2004,20(2):15-16. |
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| Authors: | Jin Wen Sun Hong Sun Lihong Du Lijun |
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| Abstract: | Objective: To study the effect of CBN from the mice brain damaged by ischemia reperfusion. Methods: The cerebral ischemia reperfusion mice is employed to investigate the protective effects of CBN, the number ofo pyramidal cells at field CA1 of hippocampus, activity of superoxide dismutase (SOD) and adenosine 5 triphosphoratase (ATPase), contents of reduced malondialdehyde (MDA) in experimental mouse brain were measured. Results: Cerebral ischemia reperfusion resulted in the decreasing of number of pyramidal cells, SOD, ATPase and the increasing of MDA, could reverse them individually. Conclusion: CBN showed the protective effects against the injury of ischemia reperfusion in brain by reducing lipid peroxide, scavenging free radicals and improving the energy metabolism. |
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| Keywords: | CBN SOD MDA ATPase |
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