| 注射用复方氨苄西林钠的家兔体外抗菌实验 |
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| 引用本文： | 贺立泽,王佩贤,姚鸿萍,曹永孝.注射用复方氨苄西林钠的家兔体外抗菌实验[J].亚太传统医药,2007,3(10):52-55. |
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| 作者姓名： | 贺立泽 王佩贤 姚鸿萍 曹永孝 |
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| 作者单位： | 1. 广州安健实业发展有限公司,广东,广州,510420;西安交通大学药学院,陕西,西安,710001
2. 西安交通大学药学院,陕西,西安,710001 |
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| 基金项目： | 陕西省卫生厅科研基金项目（04D30）,注射用复方氨苄西林钠抗菌作用和药代动力学研究. |
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| 摘 要： | 目的:考察注射用复方氨苄西林钠的家兔体外抗菌特征。方法:体外抗菌考察单次和多次给家兔注射复方氨苄西林钠后,采集的家兔血浆对培养的金黄色葡萄球菌和大肠杆菌的抗菌作用。结果:与注射用氨苄西林钠组相比,注射用复方氨苄西林钠大、中、小剂量组增强了氨苄西林钠对金黄色葡萄球菌和大肠杆菌的抑菌作用(p<0.05或p<0.01)。结论:与注射用氨苄西林钠组相比,注射用复方氨苄西林钠可增强氨苄西林钠的抗菌作用。
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| 关 键 词： | 注射用复方氨苄西林钠 注射用氨苄西林钠 抗菌作用 |
| 文章编号： | 1673-2197（2007）10-052-03 |
Anti-infection effect of Compound Ampicillin Sodium for Injection in rabbits |
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| He Lize, Wang Peixian.Anti-infection effect of Compound Ampicillin Sodium for Injection in rabbits[J].Asia-Pacific Traditional Medicine,2007,3(10):52-55. |
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| Authors: | He Lize Wang Peixian |
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| Abstract: | Objective:Test the antibiotics effect of Compound Ampicillin Sodium for Injection in rabbits.Methods:In vito,investigated Compound Ampicillin Sodium for Injection on antibiotics effect of staphylococcus and Escherichia coli after single and multiple dose administration with method of cup-plate method.Results:Compared with Ampicillin Sodium for Injection,Compound Ampicillin Sodium for Injection 300 mg·kg-1、120 mg·kg-1 and 50 mg kg-1 could significantly increase the concentration of ampicillin sodium in plasma of rabbits(p<0.05 or p<0.01)and increase the effect of bactericide action on staphylococcus and Escherichia coli.Conclusion:Compared with Ampicillin Sodium for Injection,Compound Ampicillin Sodium for Injection could increase the anti-infection effect of ampicillin sodium. |
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| Keywords: | Compound ampicillin sodium Ampicillin sodium for injection Anti-infection effect |
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