Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia |
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Authors: | Sala-Vila A Cofán M Mateo-Gallego R Cenarro A Civeira F Ortega E Ros E |
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Institution: | aEndocrinology and Nutrition Department, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain;bCiber Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spaine;cLipid Clinic and Molecular Investigation Laboratory, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain;dCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, Spainf |
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Abstract: | Background & aimsData on intake of oleic acid (OA) and insulin resistance (IR) are inconsistent. We investigated whether OA in serum phosphatidylcholine relates to surrogate measures of IR in dyslipidaemic subjects from a Mediterranean population.MethodsCross-sectional study of 361 non-diabetic subjects (205 men, 156 women; mean age 44 and 46 y, respectively; BMI 25.7 kg/m2). IR was diagnosed by BMI and HOMA values using published criteria validated against the euglycemic clamp. Alternatively, IR was defined by the 75th percentile of HOMA-IR of our study population. The fatty acid composition of serum phosphatidylcholine was determined by gas-chromatography.ResultsThe mean (±SD) proportion of OA was 11.7 ± 2.0%. Ninety-two subjects (25.5%) had IR. By adjusted logistic regression, including the proportions of other fatty acids known to relate to IR, the odds ratios (OR) (95% confidence intervals) for IR were 0.75 (0.62–0.92) for 1% increase in OA and 0.84 (0.71–0.99) for 1% increase in linoleic acid. Other fatty acids were unrelated to IR. When using the alternate definition of IR, OA remained a significant predictor (0.80 0.65–0.99]).ConclusionsHigher phospholipid proportions of OA relate to less IR, suggesting an added benefit of increasing olive oil intake within the Mediterranean diet. |
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Keywords: | Biomarker HOMA-IR Mediterranean diet Olive oil Phospholipid fatty acids |
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