Effect of essential amino acid supplementation on quality of life, amino acid profile and strength in institutionalized elderly patients |
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Authors: | Rondanelli Mariangela Opizzi Annalisa Antoniello Neldo Boschi Federica Iadarola Paolo Pasini Evasio Aquilani Roberto Dioguardi Francesco Saverio |
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Institution: | aDepartment of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, Metabolic and Nutrition Unit, Azienda di Servizi alla Persona di Pavia, University of Pavia, Via Emilia 12, 27100 Pavia, Italy;bAzienda di Servizi alla Persona di Pavia, Italy;cDepartment of Experimental and Applied Pharmacology, University of Pavia, Italy;dDepartment of Biochemistry “A. Castellani”, University of Pavia, Italy;eCardiology Division, S. Maugeri Foundation, IRCCS Scientific Institute of Lumezzane, Brescia, Italy;fMetabolic Service and Nutrition Pathophysiology, S. Maugeri Foundation, IRCCS Scientific Institute of Montescano, Pavia, Italy;gDepartment of Internal Medicine, University of Milan, Italy |
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Abstract: | Background & aimsThis study assessed the efficacy of supplemented essential amino acids on depressive symptoms, nutrition, muscle function, daily physical activity, and health-related quality of life (HRQoL) of institutionalized elderly patients.MethodsForty-one patients (58.5% women; mean age 79.8 yrs) with sequelae of coronary artery disease (73%), femoral fracture (34%), were randomly assigned to receive oral essential amino acids 4 gr 2 times a day for 8 weeks or isocaloric placebo. Before randomization and 8 weeks after the protocol started, the following variables were measured: depressive symptoms (Geriatric Depression Scale, GDS), nutritional panel (Mini Nutritional Assessment, MNA; serum albumin and prealbumin levels), muscle strength (Hand Grip, HG), Activity Daily Life (ADL), Quality of Life (SF-36, HRQoL) and amino acid profile.ResultsCompared with the placebo group, EAA patients improved nutrition (MNA score 22.6 ± 1.5 post vs 21.8 ± 1.6 pre; p < 0. 04, albumin g/dl 4.04 ± 0.35 post vs 3.88 ± 0.3 pre; p < 0.01), GDS(score 10.3 ± 1.75 post vs 13.85 ± 3.37 pre; p < 0.001), HG (Kg 19.75 ± 1.7 post vs 18.68 ± 1.36 pre; p = 0.001), ADL (p < 0.04) and both physical and mental components of SF-36 (p < 0.002).ConclusionsOral supplementation with essential amino acids improved several determinants of quality of life in institutionalized elderly patients, including depressive symptoms, nutrition, muscle function and daily life activity. |
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Keywords: | Elderly Amino acid Nutrition Dietary supplement Health-related quality of life Muscle strength |
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