| 肝肾功能损害状态下蝙蝠葛碱的药动学 |
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| 引用本文： | 桂耀庭,代宗顺,曾繁典,胡崇家.肝肾功能损害状态下蝙蝠葛碱的药动学[J].中国药理学通报,1991(6). |
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| 作者姓名： | 桂耀庭 代宗顺 曾繁典 胡崇家 |
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| 作者单位： | [1]同济医科大学临床药理研究室 [2]汉口430030 [3]同济医科大学计划生育研究所 |
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| 摘 要： | 以HgCl_2所致家兔急性中毒性肾功衰(ARF)和CCl_4所致急性中毒性肝损害(ALI)为模型,研究蝙蝠葛碱(Dau)在肝肾功能损害状态下的药代动力学。结果表明:ARF组的药代动力学参数与正常对照组无显著性差异。ALI组α,t1/2α,V_d,V_c与正常对照组无显著差异,其β,K_(10),Cl值均显著低于正常对照组,其t1/2β值显著高于正常对照组。
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| 关 键 词： | 蝠蝙葛碱 药代动力学 急性中毒性肾功衰 急性中毒性肝损害 |
THE PHARMACOKINETICS OF DAURICINE IN RABBITS WITH EXPERIMENTAL ACUTE RENAL FAILURE OR ACUTE LIVER INJURY |
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| Gui Yaoting,Dai Zhongshun,Zeng Fandian,Hu Chongjia.THE PHARMACOKINETICS OF DAURICINE IN RABBITS WITH EXPERIMENTAL ACUTE RENAL FAILURE OR ACUTE LIVER INJURY[J].Chinese Pharmacological Bulletin,1991(6). |
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| Authors: | Gui Yaoting Dai Zhongshun Zeng Fandian Hu Chongjia |
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| Abstract: | Dauricine ( Dau ) was studied on the pharmacokinetics in experimental acute renal failure (ARF ) induced by HgCl2 or acute liver injury ( ALI ) induced by CC14 in rabbits.
After iv administration of 5 mg/kg in normal rabbits the main pharmacokinetic parameters of Dau were as follows:t1/2=0.18±0.12 (h), t1/2β=3.18±0.95 ( h ) , Vd = 26.7l± 3.61 ( L/kg ) and Cl = 6.91 ± 1.74 ( L/h·kg-1 ). The pharmacokinetic parameters of Dau in ARF were not significantly different from that in normal. Cl (3.31±1.88 L/h·kg-1 ) in ALI was significantly lower than that in normal and t1/2β ( 8.85±4.57 h ) in ALI was considerably longer than that in normal.
The results indicated that the pharmacokiaetics of Dau had no change in rabbits with ARF and its elimination was prolonged in rabbits with ALI. |
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| Keywords: | Dauricine Pharmacokinetics Experimental acute renal failure Experimental acute liver injury |
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