载脂蛋白E基因多态性对血脂康胶囊调脂作用的影响

目的 探讨载脂蛋白E(ApoE)基因多态性对血脂康胶囊调脂作用的影响。

Influence of Apolipoprotein E Gene Polymorphism on the Lipid Regulation by Xuezhikang Capsule

Objective To explore the influence of apolipoprotein E （ApoE） gene polymorphism on the lipid metabolism regulatory effect of Xuezhikang Capsule （XZKC）. Metheds ApoE polymorphism of 74 patients with hyperlipidemia was detected by gene sequencing method, and their plasma levels of total cholesterol （TC）, triglyceride （TG）, high- and low-density lipoprotein cholesterol （HDL-C and LDL-C） were determined before and after they received a 6-week treatment of XZKC, for analyzing the relationship between ApoE gene polymorphism and the changes of various blood lipids associated indices. Results The effect of XZKC on reducing TG in the E2 allele （E2/E2 and E2/E3 genotypes） was higher than that in the E3/E3 genotypes and E4 allele （ E3/E4 and E4/E4 genotypes）, while on increasing HDL-C, it showed more effect in the E4 allele （ E3/E4 and E4/E4 genotypes） than that in the E2 allele （ E2/E2 and E2/E3 genotypes） and E3/E3 genotypes. Conclusion Patients＇ ApoE gene polymorphism could influence the lipid regulatory effect of XZKC, embodying mainly by raising HDL-C and reducing TG in patients with different ApoE genotypes to different extents.