| Study on CO_2-supercritical fluid extraction used to extract three kinds of tanshinones from the root of salvia meltiorrhiza bunge with different entrainers |
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| 作者姓名： | Guozhang Li Huazhong Yu Xiaoying Bu Yong Cao Liqun Rao |
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| 作者单位： | Guozhang Li 1，2，Huazhong Yu1，Xiaoying Bu1，Yong Cao1 and Liqun Rao2 1Key Laboratory of Hunan Forest Product and Chemical Industry Engineering，Jishou University，Zhangjiajie 427000，China; 2College of Biological Science and Technology，HNAU，Changsha 410128，China |
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| 摘 要： | INTRODUCTION ChinesetraditionalmedicineDanshen(driedrootofSalviamiltiorrhizaBunge)containslotsof bioactivecomponents.Fat solubletanshinonesarethe mostimportant,includingcryptotanshinone,tanshinoneⅠ,tanshinoneⅡA,tanshinoneⅡB.Thesesubstances havevarieddimensionalmolecularstructurebutsimilar biologicalproperties.Recentstudiesshowthat tanshinoneⅠhasanti tumoreffect1]andtanshinoneⅡAcanobviouslyinhibitthegrowthofseveraltumor celllines,especiallyNB4cells2,3].Studiesalsosuggest thattans…
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Study on CO2-supercritical fluid extraction used to extract three kinds of tanshinones from the root of salvia meltiorrhiza bunge with different entrainers |
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| Guozhang Li,Huazhong Yu,Xiaoying Bu,Yong Cao,Liqun Rao.Study on CO_2-supercritical fluid extraction used to extract three kinds of tanshinones from the root of salvia meltiorrhiza bunge with different entrainers[J].Acta Universitatis Medicinalis Nanjing,2006,20(2). |
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| Authors: | Guozhang Li Huazhong Yu Xiaoying Bu Yong Cao Liqun Rao |
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| Abstract: | Objective: To extract three kinds of tanshinones from the root of Salvia miltiorrhiza Bunge by CO_2-supercritical fluid extraction technology with different entrainers at different flow rates, and to investigate the effects of different entrainers. Methods: Three kinds of tanshinones were extracted at the optimal operation condition, and the massconcentration of three kinds of tanshinones in the extracts was determined by HPLC. Results: Among the three entrainers,the extracting effects of ethanol is the best, for the stronger polarity, followed by ethanol and normal octane. Conclusion: To increase the extracting rate of three kinds of tanshinones by CO_2- supercritical fluid extraction technics, it is essential to use polar solvent as entrainer. |
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| Keywords: | tanshinones CO2-SF extraction entrainer extraction effect |
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