| 对苯二甲酸遗传毒性研究 |
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| 引用本文： | 龚楠,徐锡坤,王心如. 对苯二甲酸遗传毒性研究[J]. 中国公共卫生学报, 1999, 0(4) |
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| 作者姓名： | 龚楠 徐锡坤 王心如 |
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| 作者单位： | 南京医科大学公共卫生学院 |
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| 基金项目： | 国家卫生部和江苏省科委自然科学基金 |
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| 摘 要： | 对对苯二甲酸（ＴＰＡ）的急性毒性和遗传毒性进行初步研究。结果显示，ＢＡＬＢ／Ｃ小鼠和ＳＤ大鼠急性经口ＬＤ５０均大于１５０００ｍｇ／ｋｇ；Ａｍｅｓ试验以ＴＡ９７、ＴＡ９８、ＴＡ１００和ＴＡ１０２作为测试菌种，在有无代谢活化系统的情况下，结果均为阴性；ＴＰＡ诱导的昆明种小鼠骨髓微核发生率无明显增加；ＴＰＡ体外诱导的ＣＨＬ细胞染色体畸变率与对照组相比无显著性差异。提示，ＴＰＡ具有致突变活性的可能性极小。
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| 关 键 词： | 对苯二甲酸 急性毒性 遗传毒性 |
Study on the Acute Toxicity and Genotoxicity of Terephthalic Acid |
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| Gong Nan,et al.. Study on the Acute Toxicity and Genotoxicity of Terephthalic Acid[J]. , 1999, 0(4) |
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| Authors: | Gong Nan et al. |
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| Affiliation: | Nanjing 210029 |
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| Abstract: | The acute and genetic toxicity of Terephthalic Acid(TPA) showed that (1) LD 50 in BALB/C and SD rat were found to be more than 15000mg/kg respectively by oral administration,(2)the genotoxicity was negative based on the Ames test by using Salmonella typhimurium strains TA97,TA98,TA100 and TA102,with or without a liver S 9 metabolic activating system,(3)in the bonemarrow micronucleus test in Kumming mouse,micronucleus incidence induced by TPA was not incrased with TPA conentration,and,(4)the fact that the frequency of chromsome aberration of treatment groups was not higher than that of the control group suggests that the mutagenic activeity of TPA is not significant. |
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| Keywords: | Terephthalic acid Acute toxicity Genotoxicity |
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