别嘌醇过敏综合征

1例46岁男性患者因血尿酸高给予别嘌醇0.2g,2次/d。28d后躯干及四肢出现大片水肿性红斑伴瘙痒。遂停用别嘌醇。随后症状加重,全身泛发性潮红、肿胀伴紫癜,眼睑水肿,口周渗出、结痂。实验室检查：WBC20.2×109/L,E0.32,ALT52U/L。骨髓涂片检查示嗜酸细胞增多。给予甲泼尼龙80mg加入5%葡萄糖注射液250mL静脉滴注。3d后症状好转。

Allopurinol hypersensitivity syndrome in a patient

A 46-year-old male patient received allopurinol 0. 2 g twice daily for hyperuricaemia. After 28 days of therapy,the patient experienced sheeted edematous erythema with itching on his trunk and extremities. Allopurinol was stopped. Subsequently,his symptoms worsened and he presented with generalized flushing,and swelling with purpura,palpebral edema,perioral exudation and sabbing. Laboratory examinations revealed a WBC count of 20. 2 × 109 /L with 0. 32 eosinophils and an ALT level of 52 U/L. A bone marrow smear showed his eosinophils increased. The patient was treated with an IV infusion of methylprednisolone 80 mg dissolved in 5% glucose 250 mL. Three days later,his symptoms improved.