兔VX2肝癌模型动态磁共振灌注成像的量化研究

目的 探讨对兔VX2种植型肝癌模型的成瘤过程进行动态磁共振灌注成像量化研究的可行性及价值。方法对16只新西兰大白兔VX2种植型肝癌模型和4只正常新西兰大白兔，在实验兔接种后14、18、22、26d分别行磁共振成像及磁共振灌注成像；动态量化分析平均强化时间、最大增强斜率的变化规律并与病理结果对照。结果 兔VX2种植型肝癌模型随成瘤过程时间的延长其平均强化时间的均值呈递增趋势，最大增强斜率的均值呈递减趋势，与对照组间存在显著性差异；病理结果多项分析中，瘤内凝固性坏死和纤维增生呈明显递增趋势。结论 磁共振灌注成像的量化指标能够动态观测兔VX2种植型肝癌模型部分生长特性：为磁共振灌注成像对肝脏病变的临床应用提供一定的理论指导。

Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic VX2 tumor

Objective To investigate the possibility of dynamic magnetic resonance(MR)perfusion-weighted imaging(PWI)in rabbit models of implanted hepatic VX2 tumor.Methods MRI and PWI images were obtained from 16 rabbit models of implanted hepatic VX2 tumor and 4 normal rabbits at 14,18,22,and 26 days after tumor implantation,respectively,and the mean time to enhancement(MTE)and maximum slope of increase(MSI)were estimated and compared with pathological changes.Results In the rabbit models of implanted hepatic tumor the MTE tended to increase and MSI to descend 14,18,22,and 26 days after tumor implantation,showing significant differences from the control group.Coagulation necrosis and fibrous hyperplasia in the tumors appeared to progress with time as found pathologically.Conclusion Dynamic MR PWI quantitative analysis of rabbit models of implanted hepatic VX2 tumor provides valuable means for observing the growth behaviors of VX2 tumor and may be clinically applicable in the evaluation of hepatic diseases.