乳腺浸润性导管癌雌、孕激素受体及人类上皮生长因子受体表达与超声特征的关系

目的 探讨乳腺浸润性导管癌(IDC)患者雌激素受体(ER)、孕激素受体(PR)、人类上皮生长因子受体(HER-2)表达水平与灰阶超声特征的相关性.方法 对术前应用超声检查的73例IDC患者的灰阶超声图像特征与术后标本经免疫组织化学染色检测ER、PR、HER一2表达情况进行对比研究.结果 肿瘤有毛刺(蟹足)征、周边高回声晕、肿瘤后方衰减组ER阳性表达率高于肿瘤无毛刺(蟹足)征、无周边高回声晕、肿瘤后方无衰减组,差异有统计学意义(P＜0.01);肿瘤内微钙化、腋窝肿大淋巴结组HER-2表达阳性率高于肿瘤内无微钙化、腋窝无肿大淋巴结组,差异有统计学意义(P＜0.05).结论 ER、HER-2表达与IDC灰阶超声特征之间存在相关性,灰阶超声征象可对部分乳腺浸润性导管癌的预后及生物学特性作出初步判断.

Correlation between grey scale ultrasonographic feature and estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in infiltrating ductal cancer of breast

Objective To evaluate the relationship between the grey scale ultrasonographic feature and estrogen receptor(ER),progesterone receptor(PR)or human epidermal growth factor receptor-2(HER-2)expression in infiltrating ductal cancer(IDC)of breast.Methods Seventy-three patients with IDC confirmed pathologically were involved in this study.The specimens wete examined immunohistochemistically to judge the expression of the related factors.ER,PR and HER-2 expression of the mastectomy specimens were determined with immunohistochemical staining technique.The correlation between the ultrasonographic features and ER,PR or HER-2 positive expression was analyzed. Results The ER positive rate in lesions with the spicule sign,echogenic halo or posterior shadowing were higher than in lesions without the spicule sign,echogenic halo or posterior shadowing(P＜0.01).The HER-2 positive rate in lesion with the calcifications and lymphadenectasis in axillary was higher than that in lesions without calcifications,or lymphadenectasis in axillary(P＜0.05).Conclusions A certain correlation exists between the ultrasonographic features and ER,HER-2 expression in patients with IDC.