| 孤束核和延髓尾端腹外侧区内微量注射GABA对肾交感传出活动及血压的影响 |
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| 引用本文： | 陆杰,王莎莉,黄仲荪.孤束核和延髓尾端腹外侧区内微量注射GABA对肾交感传出活动及血压的影响[J].重庆医科大学学报,1994(4). |
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| 作者姓名： | 陆杰 王莎莉 黄仲荪 |
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| 摘 要： | 实验在３１只兔身上进行。利用自制的刺激电极和微量灌注管对核团进行刺激和微量灌注。观察到一侧孤束核（ＮＴＳ）和脑干网状结构尾端腹外侧区（ｃＶＬＭ）内微量注入ｒ－氨基丁酸（ＧＡＢＡ）后，电刺激ＮＴＳ引起肾交感神经放电反应（ＮＴＳ－ＳＮＤ）的抑制效应明显减弱，可持续１０～１５分钟。说明在兔ＮＴＳ和ｃＶＬＭ中含有对肾交感神经放电和血压调控的ＧＡＢＡ能系统。而ＮＴＳ对交感神经放电抑制和使血压下降至少部分是通过ｃＶＬＭ中的ＧＡＢＡ受体发挥作用的。
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| 关 键 词： | 交感神经放电，动脉血压，孤束核，r－氨基丁酸，延髓网状结构尾端腹外侧区 |
THE EFFECT OF GABA MICROINJECTION INTO THE NUCLEUS TRACTUS SOLITARII(NTS)AND CAUDAL VENTROLATERAL MEDULLA(cVLM) ON THE RENAL SYMPATHETIC DISCHARGE AND BLOOD PRESSURE IN RABBITS |
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| Lu Jie,et al.THE EFFECT OF GABA MICROINJECTION INTO THE NUCLEUS TRACTUS SOLITARII(NTS)AND CAUDAL VENTROLATERAL MEDULLA(cVLM) ON THE RENAL SYMPATHETIC DISCHARGE AND BLOOD PRESSURE IN RABBITS[J].Journal of Chongqing Medical University,1994(4). |
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| Authors: | Lu Jie |
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| Institution: | Dept. of Physiology |
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| Abstract: | xperiments were performed on 31 rabbits. The technique provides a highly localized drug adminstrationand electrical stimulation on NTS. Ipsilateral microinjection of r-amino butyric acid(GABA) into NTS orcVLM could diminish the SND inhibitory and depressor responses elicited by electrical stimulation of NTS. These responses usually lasted 10-15 min, The results of the present study indicate that there is GABAergicsystem responsible for SND and arterial pressure control in the NTS and cVLM of the rabbit.The sympatho- inhibitory responses evoked from NTS are mediated ,at least in part by GABA receptors in the cVLM. |
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| Keywords: | Sympathetic Nerve Discharge iArterial Blood Pressure Nucleus Tractus Solitarii Gamma-aminobutyric Acid(GABA) caudal ventrolateral Medulla |
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