高氧对缺血缺氧新生大鼠远期学习记忆能力的影响

目的 探讨高氧对缺血缺氧新生大鼠生后学习记忆能力的影响，为临床缺血缺氧疾病的治疗提供实验依据。方法 通过左侧颈总动脉结扎制作新生大鼠缺血缺氧性脑损伤模型，给予 60％高氧干预 72 小时，新生大鼠饲养两个月后，利用水迷宫检测大鼠学习记忆能力。结果 高氧组的逃避潜伏期时间平均为 55.87±6.23s，明显高于对照组（P＜0.05）；高氧组大鼠穿越原平台位置的次数和在原平台象限游程、时间百分比均低于对照组（P＜0.05）。结论 高氧干预可能降低缺血缺氧新生大鼠生后学习记忆能力。

Effect of High Oxygen on Learning and Memory Ability of Long-Term Hypoxia lschemia in Neonatal Rats

Objective To investigate the effect of hyperoxia on learning and memory ability of hypoxia ischemia in neonatal rats after birth,to provide the experimental basis for the clinical treatment of hypoxia ischemic diseases. Methods Newborn rats with hypoxie ischemie brain injury model by left carotid artery ligation,were given 60% high oxygen intervention for 72 hours,and after two months of feeding, rats were examined for the ability of learning and memory in water maze test. Results In high oxygen group the average time of escape latency is （55.87±6.23）s,significantly higher than that of control group （P〈0.05） ;the number of high oxygen group rats crossing the original platform and in the original platform quadrant run was reduced,the percentage of time were lower than that of control group （P〈0.05）. Conelusion High oxygen intervention could decrease the learning and memory ability of hypoxia isehemia in neonatal rats after birth.