炼油污水挥发物对作业工人脂质过氧化反应的影响

目的 探讨低浓度炼油污水作业对人体氧化和过氧化反应的影响。方法 检测73例污水处理作业工人和129例健康对照血清丙二醛（MDA）含量和血清超氧化物歧化酶（SOD）、全血谷胱甘肽过氧化物醇（GSH－Px)和过氧化氢酶（CAT）活力。结果 污水处理作业工人血清SOD和全血GSH－Px活力与对照组相比，差异具有显著性（P＜0．01），CAT的差异不具有显著性。中工龄组（5－20年）GSH－Px活力明显高于对照组，而高工龄组（＞20年）差异不具有显著性。接触组SOD活力仅低工龄组（＜5年）较对照组高（P＜0．05）。结论 低浓度长期接触炼油污水挥发物，体内的脂质过氧化反应和抗氧化机制均处于亢奋状态，后者可能是机体的一种防御机制。

Effect of Lipid Peroxidation in Workers Exposed to Volatiles from Oil Refinery Wastewater

Objective The effect of oxidation and peroxidation in workers exposed to oil refinery waste water in low concentration was observed.Methods Contents of malonaldehyde(MDA)and activity of superoxide dismutase(SOD)in serum,and activities of glutathione peroxidase(GSH-Px)and catalase(CAT)in whole blood of 73 workers exposed to oil refinery waste water and 129 control workers never exposed to hazardous chemicals were examined.Results Comparing with control workers,the activities of SOD in serum and GSH-Px in whole blood of exposed workers were significantly higher(P<0 01),while activity of CAT had no obvious change in these two groups.Activity of GSH-Px in those <20 yrs.of working age in the exposed group was obviously \{higher\} than that of the control group.However,no significant change in the exposed group with >20 yrs. of working age was found.Only the activity of SOD in exposed group with <5 yrs. of working age was higher than that of the control group(P<0 05).Conclusions With a long term exposure to low concentration volatiles from oil refinery wastewater,the activities of lipid peroxidation and anti oxidation were under stimulated condition,which might be a defensive mechanism of the body.