慢性肾炎患者治疗前后血清IL-2、IL-6和TNF-α检测的临床意义

目的：探讨了慢性肾炎患者治疗前后血清IL-2、IL-6和TNF-α水平的变化及临床意义。方法：应用放射免疫分析对32例慢性肾炎患者进行了血清IL-2、IL-6和TNF-α水平测定,并与35名健康人作比较。结果：慢性肾炎在治疗前血清IL-6和TNF-α水平均非常显著的高于正常人组（P〈0.01）,而IL-2则显著的低于正常人组（P〈0.01）。经中西医结合治疗3个月后与正常人组比较仍有显著性差异（P〈0.05）。结论：检测慢性肾炎患者血清IL-2、IL-6和TNF-α水平的变化对观察病情及预后判定均具有重要的临床价值。

Clinical Significance of Determination of Changes of Serum IL-2, IL-6 and TNF-α Levels After Treatment in Patients with Chronic Nephritis

Objective To explore the clinical significance of changes of serum IL-2, IL-6 and TNF-α levels after treatment in patients with chronic nephritis. Methods Serum IL-2, IL-6 and TNF-α levels were measured with RIA in 32 patients with chronic nephritis both before and after treatment as well as in 35 controls. Results Before treatment, serum IL-6 and TNF-α levels in the patients were significantly higher than those in controls （P〈0.01）, but IL-2 levels were significantly lower （P〈0.01）. After treatment for 3 months, the serum IL-2, IL-6 and TNF-α levels, though markedly corrected, remained significantly different from those in controls （P〈0.05）. Conclusion Detection of serum IL-2, IL-6 and TNF-α levels after treatment might be of prognostic importance in patients with chronic nephritis.