基于CT的肺容量测算法在早发性脊柱侧弯诊疗中的应用

目的 通过对比基于CT的肺容量测算结果与常规肺功能检查结果之间的相关性,评估CT测量肺容量法的可靠性和临床意义.方法 选取北京儿童医院骨科入院治疗的共计40例早发性胸段脊柱侧弯患儿,行肺功能检查和CT检查.应用手绘-分层测量求和法测量患儿肺容量并计算其与预计值之间比例.将结果与患儿常规肺功能结果进行对比,利用文献报道的CT测量的肺容量正常值作为标准数据,比较基于CT的肺容量实测值/预计值与肺功能相应结果的相关性;比较Cobb's角与凹侧、凸侧肺容量比及肺功能结果之间关系.结果基于CT肺容量结果最大肺活量(VCmax)、用力肺活量(FVC)、肺总量(TLC)平均值低于肺功能检查结果.但与常规肺功能结果的相关性具有统计学意义:VCmax(P<0.001)、FVC(P<0.001)、TLC(P<0.001);基于CT的肺容量实测值/预计值比例与肺功能结果相关性均有统计学意义:Vcmax%(P<0.001)、FVC%(P<0.001)、TLC%(P<0.001);Cobb's角与凹侧、凸侧肺容量比及肺功能结果均无明显关联.结论 基于CT的肺容量测算法测量的肺容积结果与常规肺功能结果高度相关,是临床评估患儿肺脏容积的一种有效方法 .

The application of CT-based pulmonary volumetric evaluation in the diagnosis of early onset scoliosis

Objective To evaluate the accuracy of the application of CT-based pulmonary volu-metric evaluation to diagnose early onset seoliosis. Methods Forty patients with early-onset thoracic scoliosis were enrolled in this study. All patients had CT scan and pulmonary function test (PFT). Handdraw-layers summation method was carried out to calculate patients'lung volume on CT scan. The reference CT-based lung volume was defined as the corranonly'accepted data reported in litera-tures. The ratio of CT-based patients'lung volume to the reference CT-based lung volume was calcu-lated. The correlation between the calculated ratio and corresponding PFT results was analyzed statis-tically. The correlations between Cobb's angle and concave/convex lung's volume and PFT results were also analyzed. Results Compared to the lung volume of VCmax、FVC、TLC evaluated by PFT,the CT-based lung volume was underestimated. However,the correlation of the lung volume estimated by 2 methods was significant. No significant correlation was found between Cobb's angle or concave/con-vex lung's volume and PFT results. Conclusions Conclusions CT-based Pulmonary Volumetric Evalua-tion is a useful way to evaluate the lung's volume and diagnose early onset scoliosis.