非那雄胺对不同年龄组雄激素性脱发患者的疗效观察

目的评价非那雄胺1mg/d治疗不同年龄组雄激素性脱发(AGA)男性患者的疗效及安全性。方法选取117名符合Norwood/Hamilton分级Ⅲ～Ⅴ级及Ludwing分级Ⅰ～Ⅱ级的AGA患者,按年龄分为两组:I组(≤26岁)、II组(26岁),均每日口服非那雄胺1mg,连续12个月。结果Ⅰ组在治疗第3,6,9,12个月的有效率分别是为42.31%,65.38%,88.46%,96.15%;Ⅱ组分别为28.33%,46.67%,73.33%,80.00%。在治疗6个月、9个月和12个月时Ⅰ组和Ⅱ组的有效率差异均有统计学意义(P均0.05)。结论每日口服1mg非那雄胺能安全有效的治疗AGA,且疗效与年龄相关,≤26岁的患者疗效更佳。

Study on the Efficacy and Safety of Finasteride on the Treatment of Men with AGA in Different Age Groups

Objective To evaluate the efficacy and safety of 1mg/d oral finasteride on the treatment of men with Androgenetic alopecia(AGA) in different age groups. Methods One hundred and seventeen men with AGA (Stage Ⅲ to V of Norwood/Hamilton Classification and stage Ⅰ toⅡof Ludwing Classification) were divided into two groups according to the different age:group Ⅰ(≤26 years)and group Ⅱ(>26years). All patients were required to receive finasteide(1mg/d) for 1 year. Results After treatment in 3,6,9 and 12 months, the effective rate in group Ⅰ were 42.31%,65.38%,88.46% and 96.15%,respectively, and in group Ⅱ were 28.33%,46.67%,73.33% and 80.00%,respectively. In these two groups,the effective rates on the periods of 6,9 and 12 months have the significant difference (P<0.05). Conclusion The treatment of AGA with 1mg/d oral finasteride is effective and safe. There were positive correlation between age and efficacy. In the group of patients ≤26 years have the better efficacy.