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Laparoscopic Adjustable Gastric Banding Reduces Subcutaneous Adipose Tissue and Blood Inflammation in Nondiabetic Morbidly Obese Individuals
Authors:Laura Iaffaldano  Carmela Nardelli  Vincenzo Pilone  Giuseppe Labruna  Andreina Alfieri  Donatella Montanaro  Maddalena Ferrigno  Maria Restituta Zeccolella  Nicola Carlomagno  Andrea Renda  Alfonso Baldi  Pietro Forestieri  Lucia Sacchetti  Pasqualina Buono
Affiliation:1. CEINGE-Biotecnologie Avanzate S.C.a R.L., Via G. Salvatore 486, 80145, Naples, Italy
2. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy
3. Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy
4. IRCCS Fondazione SDN–Istituto di Ricerca Diagnostica e Nucleare, Via Gianturco 113, 80142, Naples, Italy
5. Dipartimento Scienze Motorie e del Benessere, Università degli Studi di Napoli Parthenope, Via Amm. F. Acton 38, 80133, Naples, Italy
6. Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy
7. Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100, Caserta, Italy
8. Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy
Abstract:

Background

Significant and sustained excess weight loss (EWL) appears to reduce the risk of obesity-related comorbidities (insulin resistance, hyperlipidemia, and inflammation), but this has been primarily shown in adult diabetic obese patients. We evaluated whether the EWL obtained 3 years after laparoscopic adjustable gastric banding (LAGB) improves the metabolic phenotype in nondiabetic morbidly obese (NDMO) individuals from south Italy.

Methods

Serum and subcutaneous adipose tissue (SAT) samples from 20 obese individuals (median BMI?=?41.5 kg/m2) before (T0) and after LAGB (T1) and from 10 controls (median BMI?=?22.8 kg/m2) were taken. Serum leptin, adiponectin, C reactive protein (CRP), and main analyte levels were evaluated by routine methods or immunoassay. In SAT, adipocyte size was measured by hematoxylin/eosin staining, cluster of differentiation 68 (CD68) macrophage infiltration marker by immunohistochemistry, and adiponectin, adiponectin receptors 1 and 2, and interleukin 6 (IL6) messenger RNAs by qRT-PCR.

Results

The average EWL was 66.7 %, and CRP, triglycerides, hepatic markers, leptin levels, homeostasis model assessment, and the leptin/adiponectin ratio were lower (p?p?p?R 2?=?0.905) of EWL (dependent variable) was explained by CD68, adiponectinemia, triglyceridemia, CRP, and total protein levels.

Conclusions

The EWL obtained 3 years after LAGB resulted in an improvement of lipid metabolism and a reduction of inflammation in NDMO patients, thereby decreasing the risk of obesity-associated diseases.
Keywords:
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