BALB／c小鼠维生素D慢性中毒的实验研究

目的通过对实验动物大、小鼠饲料配方中维生素D含量进行研究,掌握实验动物大小鼠维生素D中毒的诊断方法.方法将两种不同维生素D含量的饲料作为实验组和对照组进行BALB/c小鼠饲喂实验,对其作病理剖检及血磷、血钙值测定.结果实验组出现心肌钙盐沉积率为53.3%,对照组为0.前者血钙值是后者的1.6倍(P<0.01),血磷值差异无显著性(P>0.05).结论维生素D摄入过量可引起实验动物大、小鼠离乳率下降、心肌钙盐沉积、血钙值升高.

Investigation on Vitamin D Intoxication of BALB/c Mice

Objective In order to master the diagnosis method of vitamin D intoxication by studying vitamin D of content diets of laboratory rats and mice.Methods BALB/c mice were fed with different vitamin D content diets as experimental group and control group, pathological observations were made and blood phosphorus and blood calcium were determined. Results The rate of myocardial calcareous deposit is 53.5% in the experimental group and 0 in the control group. Blood calcium value of the former is 1.6 times that of the latter; blood phosphorus value shows no significant difference between two groups.Conclusion The decreasing of weaning rate, the myocardial calcinosis and the rising of blood calcium value in laboratory rats and mice are caused by superfluous vitamin D intake.