Comparison of acute hemodynamic effects of nitroglycerin versus diltiazem and combined acute effects of both drugs in angina pectoris |
| |
| Authors: | K F Hossack J E Eldridge K Buckner |
| |
| Affiliation: | 1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;2. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore;3. Department of Orthopedic Surgery and Sports Medicine, Mayo Clinic, Rochester, Minnesota, U.S.A.;4. Department of Orthopedics and Traumatology, Universidade Federal de São Paulo;5. Hospital Israelita Albert Einstein, Hospital Beneficiência Portuguesa de São Paulo, São Paulo, Brazil;6. Department of Orthopedic Surgery, Sengkang General Hospital, Singapore;7. Musculoskeletal Sciences Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore;1. Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.;2. Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.;3. Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.;1. Merck KGaA, Frankfurter Strasse 250, Darmstadt, 64293, Germany;2. Clinica Medica, University Milano Bicocca, Milan, Italy;3. IRCCS Multimedica, Sesto San Giovanni, Milan, Italy;1. Elective Surgery Centre, Silkeborg Regional Hospital, 8600 Silkeborg, Denmark;2. University of Southern Denmark, Department of Sports Science and Clinical Biomechanics, 5100 Odense, Denmark;3. Department of Rehabilitation, University Hospital of Copenhagen, Herlev and Gentofte, Denmark;1. School of Nursing, National Yang Ming University, Taipei City, Taiwan (ROC);2. Tungs'' Taichung MetroHarbor Hospital, Taipei, Taiwan (ROC);3. Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan (ROC);4. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan (ROC) |
| |
| Abstract: | Fifteen patients with exertional angina underwent hemodynamic monitoring and measurement of cardiac output during a control treadmill exercise test. They were then randomized to receive sustained-release nitroglycerin, 13 mg (group I) or placebo (group II). Repeat exercise testing revealed that in group I, both maximal oxygen consumption and cardiac output increased significantly. In group II neither maximal oxygen consumption nor cardiac output increased significantly. All patients then received diltiazem, 60 mg, and repeat testing was carried out 1 hour later. In group I maximal oxygen consumption and cardiac output were higher than control, but were no higher than after nitroglycerin. In group II, maximal oxygen consumption increased significantly, but the increase in cardiac output was not significant. Thus, sustained-release nitroglycerin, 13 mg, or diltiazem, 60 mg, both improve exercise performance, but the combination does not improve exercise performance to an extent greater than either drug alone. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
