| 盐酸西替利嗪的合成工艺改进 |
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| 引用本文： | 谭转云,向红琳,杨晓红,周海燕. 盐酸西替利嗪的合成工艺改进[J]. 中南药学, 2006, 4(5): 362-364 |
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| 作者姓名： | 谭转云 向红琳 杨晓红 周海燕 |
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| 作者单位： | 湖南师范大学医学院,长沙,410013 |
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| 摘 要： | 目的改进盐酸西替利嗪的合成工艺。方法氯乙氧基乙酸乙酯制成碘乙氧基乙酸乙酯后与1-[（4-氯苯基）苯甲基]哌嗪缩合，再水解、成盐得到产品。结果所得产品达到药用标准，总收率60％。结论本合成中缩合反应条件被优化，收率提高，后处理简化，适合工业化生产。
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| 关 键 词： | 盐酸西替利嗪 合成 碘乙氧基乙酸乙酯 |
| 文章编号： | 1672-2981（2006）05-0362-03 |
| 收稿时间： | 2006-01-04 |
| 修稿时间： | 2006-01-042006-04-19 |
Improvement on the synthesis of cetirizine dihydrochlorride |
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| Tan Zhuan-yun,Xiang Hong-lin,Yang Xiao-hong,Zhou Hai-yan. Improvement on the synthesis of cetirizine dihydrochlorride[J]. Central South Pharmacy, 2006, 4(5): 362-364 |
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| Authors: | Tan Zhuan-yun Xiang Hong-lin Yang Xiao-hong Zhou Hai-yan |
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| Affiliation: | Medical College of Hunan Normal University, Changsha 410013 |
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| Abstract: | OBJECTIVE To improve the synthesis of cetirizine dihydrochlorride.METHODS Cetirizine dihydrochlorride was prepared by the condensation reaction with ethyl 2-iodoethoxyacetate and 1-[(4-chlorophenyl)phenylmethyl]piperazine,and then followed by hydrolysis and salt formation with hydrochlororic acid.RESULTS The(overall) yield was 60%.CONCLUSIONS The condensation reaction was improved and could be used in mass production. |
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| Keywords: | cetirizine dihydrochlorride synthesis ethyl 2-iodoethoxyacetate |
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