黄酮类化合物对动物实验性肝损伤保护作用的研究进展

各种黄酮类化合物如黄酮类、黄酮醇类、二氢黄酮类、异黄酮类、黄烷酮类等对化学性肝损伤、药物性肝损伤、免疫性肝损伤、酒精性肝损伤、缺血/再灌注性肝损伤等实验性肝损伤均有不同程度的保护作用。这种保护作用与黄酮化合物清除自由基、抗氧化、抗脂质过氧化反应、调节免疫功能等有关。研究各种黄酮类化合物对动物实验性肝损伤的作用对于开发防治肝脏疾病的药物有重要意义。该文就近年来黄酮类化合物对动物实验性肝损伤作用的研究进展作一综述。

Research progress of the protective effect of flavanoids on experimental liver injury of animals

Various kinds of flavanoids such as flavone, flavonol, flavanone, isoflavone, flavanol and so on, have protective effects on the liver injuries, which are induced by chemicals, drugs, immunostimulation, alcohol and hepatic ischemia reperfusion in some degree. These kinds of protection are relevant to the function of flavanoids such as elimination of free radical, resistance of oxidation, resistance of lipid peroxidation, adjustment of imune function and so on. The study of the effect of flavanoids on animal experimental liver injury plays an important role in the development of drugs for prevention and treatment of liver diseases. This article is to summarize the research progress of the effect of flavanoids on experimental liver injury of animals.