| 细菌抗噬菌体感染分子机制 |
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| 引用本文： | 蒋羽,李伟,范蒙光. 细菌抗噬菌体感染分子机制[J]. 疾病监测, 2015, 30(8): 679-682. DOI: 10.3784/j.issn.1003-9961.2015.08.017 |
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| 作者姓名： | 蒋羽 李伟 范蒙光 |
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| 作者单位： | 1.内蒙古医科大学, 内蒙古 呼和浩特 010110 |
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| 基金项目： | 国家重大科学仪器设备开发专项核酸微全分析仪病原菌分子分型应用开发(No.2012YQ09019706) |
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| 摘 要： | 细菌与噬菌体间是一种寄生关系,一方面细菌抵抗噬菌体感染,另一方面噬菌体也产生抗宿主菌防御的改变。本文从细菌的被动免疫、主动防御方面综述了多种细菌抵抗噬菌体的分子机制。这其中既包括细菌生物膜的物理阻隔作用,也包括吸附抑制、注入阻滞、限制修饰系统、流产感染等机制,还包括新近发现的细菌的适应性免疫-CRISPR-Cas系统以及噬菌体排除系统。细菌与噬菌体间的竞争,不仅是自身选择压力的结果,也是彼此共进化的动力。
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| 关 键 词： | 细菌 噬菌体 抵抗 相互作用 机制 |
| 收稿时间： | 2015-06-04 |
Molecular mechanisms of bacteria resistance against phage infection |
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| Affiliation: | 1.Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China2.2. State Key Laboratory for Communicable Disease Prevention and Control, Chinese Center for Disease Control and prevention, Beijing 102206, China3.4.State Key Laboratory for Communicable Disease Prevention and Control, Chinese Center for Disease Control and prevention, Beijing 102206, China5.Inner Mongolia Autonomous Region Research Center for Endemic Disease Prevention and Treatment, Hohhot 010110, Inner Mongolia, China |
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| Abstract: | Parasitic relationship exists between bacteria and phages, on one hand, bacteria resist the infection from phages, on another hand, phages develop the abilities against host bacteria. This paper summarizes several kinds of molecular mechanisms related to passive adaptation and active defense on bacteria resistance to phage infection, including physical barrier, adsorption inhibition, preventing phage DNA injection, restriction-modification system and abortive infection, as well as adaptive immune system-CRISPR-Cas system and bacteriophage exclusion system newly found in many bacteria. The competition between bacteria and phages is not only the result of their own selection pressure, but also the dynamics of their co-evolution. |
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